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Joshua LaBaer
M.D., Ph.D.
Harvard Medical School/ Harvard Institute of Proteomics

Biography
Joshua LaBaer, M.D., Ph.D., is the Director of the Institute of Proteomics at Harvard Medical School. He attended the University of California at Berkeley as an undergraduate where he was awarded the University Medal for the Most Distinguished Graduating Senior. His studies continued at the University of California, San Francisco where he attended medical and graduate school and where he studied steroid regulation of DNA transcription and protein-DNA interactions with Dr. Keith Yamamoto. Dr LaBaer completed his clinical training at the Brigham and Women’s Hospital in Boston, where he specialized in internal medicine and the Dana-Farber Cancer Institute in Boston, where he studied medical oncology. He also pursued research interests at the Massachusetts General Hospital in Boston in the areas of breast cancer, mammalian cell cycle regulation and cell cycle checkpoint genes. He is currently an Attending Physician at the Dana-Farber Cancer Institute and holds an academic appointment through the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Together with Dr. Ed Harlow, Dr. LaBaer founded the Harvard Institute of Proteomics in the spring of 1999.

e-mail:

Webcasts:

The Dynamic Proteome: Translating Industrialized Biology to Proteins
CardioGenomics Genetics and Genetic Epidemiology course, Boston, April 2003

Publications:

Analysis of Protein - DNA Interactions
Analysis of genomic and proteomic data using advanced literature mining.
Analysis of the DNA-binding affinity, sequence specificity and context dependence of the glucocorticoid receptor zinc finger region.
FLEXGene repository: from sequenced genomes to gene repositories for high-throughput functional biology and proteomics.
Genomics, proteomics, and the new paradigm in biomedical research.
High throughput protein production for functional proteomics.
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Mining the literature and large datasets.
New functional activities for the p21 family of CDK inhibitors.
Proteome-scale purification of human proteins from bacteria.
Rapid Sequencing of Miniprep DNA Using Sequenase and End-Labeled Sequencing Primer
Regulated ectopic expression of cyclin D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression.
Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium.
The FLEXGene repository: exploiting the fruits of the genome projects by creating a needed resource to face the challenges of the post-genomic era.

Current Projects:

Mouse Models of Cardiomyopathies

Components

Harvard Institute of Proteomics



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