1. Animal Models of Cardiomyopathies

• Cardiac Hypertrophy Related to the Phosphoinositide 3-Kinase Signaling Pathway (Version 2: MgU74Av2 arrays and PMT=10%)
  PI3K
  
  • Background and Physiology
  • Downloadable Microarray Data
• Cardiac Hypertrophy Induced by the Insulin-like Growth Factor 1 Receptor
  IGF1R
  
  • Background and Physiology
  • Downloadable Microarray Data
• Congenital Heart Disease in Csx/Nkx2.5 mutant embryos
  Csx
  
  • Background and Histology
  • Downloadable Microarray Data
• Deletion of the Nk2 specific domain of the Nkx2.5
  Nk2-SD
  
  • Background
  • Downloadable Microarray Data
• Exercise Induced Hypertrophy
  Swim
  
  • Background and Physiology
  • Downloadable Microarray Data
• FVB Benchmark Data Set and Sex Comparison
  FVB
  
  • Background and Physiology
  • Downloadable Microarray Data
• Myocardial Infarction
  MI
  
  • Background, Histology and Physiology
  • Downloadable Microarray Data
  • Interactive web tutorial on Myocardial Infarction
    * note: this animation requires the Flash 6 player,
    and is currently only viewable in Windows and OS10.
    Test for the Flash Player Download Flash Player
• Overexpression of dn-p21ras as a model system for severe dilated cardiomyopathy
  Ras
  
  • Background
  • Downloadable Microaray Data
• Pressure-overload induced Cardiac Hypertrophy
  Band
  
  • Background, Histology and Physiology
  • Downloadable Microarray Data

• Hypertrophy and Heart Failure Through High Salt Diet and Exercise
  Rat Hypertrophy
  
  • Background and Physiology
  • Downloadable Microarray Data

RNA expression profiling data files are also available on our public FTP server at ftp://cg2.med.harvard.edu/pub/proj1/expts/.

Microarray Annotations can be retrieved from ftp://cg2.med.harvard.edu/pub/proj1/info

2. Human Cardiac Tissues: Control and Diseased

• Clinical Data
• Expression Profiling Data
  • Idiopathic Cardiomyopathy
  • Ischemic Cardiomyopathy
  • Patients with no cardiomyopathy

3. Sarcomere Gene Mutation Screening

• Mutation Database
• Novel mutations found
• Clinical data for probands being sequenced
• Clinical data for all patients with mutations

4. Congenital Heart Disease: Candidate Gene Analysis

• Pediatric Cardiovascular Genetics Registry
  • Phenotype Data
  • Preliminary Sequence Data
  • Congenital Cardiovascular Genetics Website

5. Population Studies / Candidate Gene Large-Scale SNP Analysis

• PGA Grid: Primary association analysis results between echocardiographic phenotype and SNP genotype in Framingham Heart Study Offspring subjects are summarized in a visual grid format. Gene-Environment Interaction results are also available from the same link.
• The Candidate Gene List contains links to much of the data of Project 5:
  • SNP discovery
  • SNP genotyping
  • raw SNP genotypes
  • SNP haplotypes
  • PGA Grid associations
• SNP data can also be downloaded as two large files (login required):
  • Information for candidate gene SNPs that were genotyped, in Excel or tab-delimited text format (updated 14-Dec-2004)
  • SNPs identified by resequencing of candidate genes, in Excel or tab-delimited text format (updated 26-April-2007)

DNA Clone Production Core

• Sequence-Verified cDNA Clones