Projects

Projects
Project 1: To establish a benchmark data set of transcriptional profiling of genetic and non-genetic murine models of cardiomyopathy
Project 2: To perform comparative transcription profiling studies of diseased and normal human myocardium
Project 3: To define sarcomere protein gene mutations that cause familial hypertrophic cardiomyopathy
Project 4: To identify genetic mutations associated with left-heart obstructive lesions
Project 5: To define DNA polymorphisms of known and newly identified candidate genes and their association with left ventricular mass, cardiac function and chamber size as well as aortic root size

Components
Component 1: Animal Models Center
Component 2: RNA Expression Analysis Center
Component 3: Mouse Physiology and Imaging Center
Component 4: Human Cardiovascular Tissue Bank
Component 5: Pediatric Cardiovascular Genetics Registry
Component 6: Cardiovascular Genetics Center
Component 7: Framingham Heart Study/ Boston University School of Medicine
Component 8: The Broad Institute
Component 9: Informatics and Data Coordinating Center
Component 10: Harvard Institute of Proteomics
Component 11: Teaching and Education
Component 12: Administration