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Overview of Project 2:

To establish changes in cardiac transcription profiles brought about by heart failure we collected myocardial samples from patients undergoing cardiac transplantation whose failure arises from different etiologies (e.g. idiopathic dilated cardiomyopathy, ischemic cardiomyopathy, alcoholic cardiomyopathy, valvular cardiomyopathy, and hypertrophic cardiomyopathy) and from "normal" organ donors whose hearts cannot be used for transplants. The transcriptional profile of the mRNA in these samples will be measured with gene array technology. Changes in transcriptional profiles can be correlated with the physiologic profile of heart-failure hearts acquired at the time of transplantation.



Participants

Position

Paul Allen Principal Investigator
Jozef Bartunek Principal Investigator
Rosemarie Maddi Co-Investigator
Richard Mitchell Consultant
Bernard De Bruyne Collaborator
Marc Goethals Collaborator
Wouter Tack Collaborator
Marc Vanderheyden Collaborator
Greg Charest Programmer
Lauren Riggi Programmer

Project Publications

Aalst, Belgium

Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography
Surgical Techniques

Institutional variability in red blood cell conservation practices for coronary artery bypass graft surgery.


Affiliated Institutions  | Sponsored by the National Heart, Lung, and Blood Institute
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