Overview of Project 2:
To establish changes in cardiac transcription profiles brought about by heart failure we collected myocardial samples from patients undergoing cardiac transplantation whose failure arises from different etiologies (e.g. idiopathic dilated cardiomyopathy, ischemic cardiomyopathy, alcoholic cardiomyopathy, valvular cardiomyopathy, and hypertrophic cardiomyopathy) and from "normal" organ donors whose hearts cannot be used for transplants. The transcriptional profile of the mRNA in these samples will be measured with gene array technology. Changes in transcriptional profiles can be correlated with the
physiologic profile of heart-failure hearts acquired at the time of transplantation.
- Familial Dataset
- Hypertrophic Dataset
- Idiopathic Dataset
- Ischemic Dataset
- "Normal" Dataset
- Post-Partum Dataset
- Viral Dataset
- Belgium Dataset of Aortic Stenosis, Congestive Cardiomyopathy and Normal LV Function
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