Images	Description
	Transverse sections of a control mouse heart (A and C) and a heart 14 days after permanent ligation of the left anterior descending artery (B and D). The anterolateral myocardium is replaced by a thin fibrous scar tissue. Panels C and D show high magnification view of normal and infarcted area of myocardium, respectively. RV, right ventricle; LV, left ventricle; v, blood vessels. Arrows in panel B indicate the borders of the infarcted area. (Click on image to enlarge)
Magnetic Resonance Imaging (MRI)
	Frontal view of a sham-operated heart at 8 weeks. Horizontal lines indicate the level of cross-sections as shown below. (Click on image to enlarge) MRI's are performed at the Center for Basic MR Research at BIDMC
	Cross-sectional view of a sham-operated heart at 8 weeks. Sections are spaced 100 microns apart. The image that clearly shows both papillary muscles (no. 9) serves as a reference section to determine the position and size of the infarct in mice that underwent ligation of the left ascending (LAD) coronary artery. LV, left ventricle; RV, right ventricle; IVS, intraventricular septum (Click on image to enlarge)
	Cross-sectional view of an infarcted heart at 8 weeks after LAD ligation. Sections are spaced 100 microns apart. Arrowheads indicate the infarcted area. The image that clearly shows both papillary muscles (no. 9) was used as a reference section to determine the position and size of the infarct. LV, left ventricle; RV, right ventricle; IVS, intraventricular septum (Click on image to enlarge)

The below images are longitudinal sections stained with Hematoxylin/Eosin, and demonstrate the progression of the thinning and deterioration of the left ventricle where the infarction took place. Click on images to see an enlarged picture of the heart.

Page last modified: 29-Jun-2004