Distribution Policies of the CardioGenomics PGA
Microarray Data:
Microarray data is released 60 days after completion of the last hybridization of an individual experiment, and after the data pass our quality control standards. In cases where the quality control criteria are not met, individual microarray experiments are repeated at highest priority as soon as the biological material becomes available in order to complete the study. All available microarray data is posted on the CardioGenomics website. The progress for individual experiments can be reviewed at http://cardiogenomics.med.harvard.edu/groups/proj1/pages/progress.html. This page is updated quarterly.
Mouse Models:
The normal (wild type) mice used by this PGA are available commercially. Distribution of knockout and transgenic mouse models developed by CardioGenomics is handled on a case by case basis. If you are interested in obtaining mice from the CardioGenomics PGA please contact Martina Schinke in the Animal Models Center.
SNP, Genotyping and Mutation Data:
Candidate SNPs are uploaded to the CardioGenomics website within 30 days of validation. All validated SNPs are also submitted to dbSNP. SNPs are generally first genotyped in multigenerational CEPH pedigrees to reconstruct haplotypes. The genotype data and the haplotype reconstructions are placed on the website within 60 days of generating the genotype data. A subset of SNPs (see overview) are then genotyped in the Framingham cohort; allele and haplotype frequencies in this cohort are placed on the website within 60 days of generating the genotype data. All data must pass and quality control standards before being posted on the CardioGenomics website.
The results page for the sarcomere mutation screen is updated
upon sequencing all exons of one gene for a panel of 32 DNA
samples (probands). Mutations that are discovered are reported
on the website within 60 days. All mutation data must pass
quality control standards before being posted.
Physiology Data:
Data will be released within 30 days of collection, and onceall quality
control criteria have been meet. All raw signals for mouse physiology will
be stored on the PhysioNet
website. Summary data and methodology can be found on the CardioGenomics site in the Project 1 section.
cDNA Clones:
To request cDNA clones please contact Joshua LaBaer at the Harvard Institute of Proteomics. Click here for
a list of completed clones.
Top of Page
Disclaimer:
THE INFORMATION, DATA, PROTOCOLS AND SOFTWARE AVAILABLE ON THIS WEB SITE ARE PROVIDED ON AN "AS IS" BASIS WITHOUT WARRANTIES OF ANY KIND, EITHER EXPRESSED OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF TITLE, NONINFRINGEMENT OF INTELLECTUAL PROPERTY, AND IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE, OWNERSHIP OR NON-INFRINGEMENT. NO WARRANTY OR REPRESENTATION IS MADE REGARDING THE USE, VALIDITY, ACCURACY, OR RELIABILITY OF THE MATERIALS AND DATA PROVIDED. IN NO EVENT SHALL THE PRESIDENT AND FELLOWS OF HARVARD UNIVERSITY AND BETH ISRAEL DEACONESS MEDICAL CENTER, NOR THEIR AGENTS OR EMPLOYEES BE LIABLE FOR ANY DIRECT, INDIRECT, SPECIAL, OR INCIDENTAL OR CONSEQUENTIAL DAMAGES, OR DAMAGES OF ANY KIND, (INCLUDING WITHOUT LIMITATION, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES, LOSS OF USE, DATA OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, INCLUDING BUT NOT LIMITED TO NEGLIGENCE.
Top of Page
Page last modified: 01-Jul-2004
|
