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Overview
The objective of the Mouse Physiology and Imaging Center is to provide comprehensive phenotypic characterization of cardiovascular physiology and function in the mouse models developed through the CardioGenomics PGA. Essential will be baseline screening of commonly used strains at different ages, since many of the pathologies of interest are temporally expressed. We will examine mice for heart rate, electrocardiograms, blood pressure, cardiac pressures, contractility and relaxation properties, cardiac output, and ejection fraction in vivo using state-of-the-art physiological assays, including echocardiography and MRI. Key to this particular effort is the development of Web-based communication paradigms and protocols for rapid dissemination of advances made through this PGA. Summary data, such as mean blood pressure or mean systolic functional indices, from these physiological studies will be made available and become resident at this website. Raw physiological signals, and eventually image files, from these studies will be made available via PhysioNet. PhysioNet provides access via the web to large collections of recorded physiologic signals and related open-source software. PhysioNet is a public service of the Research Resource for Complex Physiologic Signals and is also funded by the National Institutes of Health.
Methods and Techniques
Component 3 Publications
Participants
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